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The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing.

Abstract:

The complement system is critical for immunity against the important human pathogen Neisseria meningitidis. We describe the isolation of a meningococcal mutant lacking PPX, an exopolyphosphatase responsible for cleaving cellular polyphosphate, a polymer of tens to hundreds of orthophosphate residues found in virtually all living cells. Bacteria lacking PPX exhibit increased resistance to complement-mediated killing. By site directed mutagenesis, we define amino acids necessary for the biochem...

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Publisher copy:
10.1074/jbc.m110.154393
Journal:
Journal of biological chemistry More from this journal
Volume:
285
Issue:
44
Pages:
34259-34268
Publication date:
2010-10-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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