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N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes.

Abstract:

Antibodies to the N-methyl-d-aspartate subtype of glutamate receptor have been associated with a newly-described encephalopathy that has been mainly identified in young females with ovarian tumours. However, the full clinical spectrum and treatment responses are not yet clear. We established a sensitive cell-based assay for detection of N-methyl-d-aspartate receptor antibodies in serum or cerebrospinal fluid, and a quantitative fluorescent immunoprecipitation assay for serial studies. Althoug...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awq113

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Brain : a journal of neurology
Volume:
133
Issue:
Pt 6
Pages:
1655-1667
Publication date:
2010-06-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:fc39b134-bf8d-466b-a5df-2a055fdb4621
Source identifiers:
241082
Local pid:
pubs:241082

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