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Journal article

Dependency of direct pathway CD4+ T cells on CD40-CD154 costimulation is determined by nature and microenvironment of primary contact with alloantigen.

Abstract:

Blockade of the CD40-CD154 costimulatory pathway can inhibit CD4(+) T cell-mediated alloimmune responses. The aim of this study was to define the in vivo requirement for CD40-CD154 costimulation by CD4(+) T cells that respond to alloantigen following direct recognition. We used TCR-transgenic CD4(+) T cells that are reactive to the MHC class II alloantigen, H2A(s). An experimental in vivo model was established that allowed direct comparison of the fate of a trace population of H2A(s)-reactive...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.172.4.2163

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
172
Issue:
4
Pages:
2163-2170
Publication date:
2004-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:fc323423-160b-49b1-a980-ec1590f7cad6
Source identifiers:
135954
Local pid:
pubs:135954

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