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Journal article

Interaction of lymphokine-activated killer cells with susceptible targets does not induce second messenger generation and cytolytic granule exocytosis.

Abstract:

CTL activation by specific targets leads to a rapid rise of inositol phosphates (InsPs) and of cytoplasmic-free Ca2+ concentration ([Ca2+]i). While these events are considered necessary to trigger granule secretion, Ca2+-independent cytolytic mechanisms have been recently proposed in addition or as an alternative to the classical Ca2+-dependent exocytosis model. We observed that lymphokine-activated killer (LAK) cells, obtained after stimulation with supraoptimal concentrations of IL-2 in sho...

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Publication status:
Published

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Publisher copy:
10.1084/jem.170.3.665

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Journal of experimental medicine More from this journal
Volume:
170
Issue:
3
Pages:
665-677
Publication date:
1989-09-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:35230
UUID:
uuid:fc310201-7c95-496b-ad4f-946a5e8ab671
Local pid:
pubs:35230
Source identifiers:
35230
Deposit date:
2012-12-19

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