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Macrophage heterogeneity in tissues: phenotypic diversity and functions.

Abstract:

During development and throughout adult life, macrophages derived from hematopoietic progenitors are seeded throughout the body, initially in the absence of inflammatory and infectious stimuli as tissue-resident cells, with enhanced recruitment, activation, and local proliferation following injury and pathologic insults. We have learned a great deal about macrophage properties ex vivo and in cell culture, but their phenotypic heterogeneity within different tissue microenvironments remains poo...

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Publication status:
Published

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Publisher copy:
10.1111/imr.12223
Publisher:
Blackwell Publishing Ltd
Journal:
Immunological reviews More from this journal
Volume:
262
Issue:
1
Pages:
36-55
Publication date:
2014-11-01
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
Language:
English
Keywords:
Pubs id:
pubs:488125
UUID:
uuid:fc1e8189-5f47-4ad8-b935-624d907e9648
Local pid:
pubs:488125
Source identifiers:
488125
Deposit date:
2014-11-08

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