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Longitudinal study to assess the quantitative use of fundus autofluorescence for monitoring disease progression in choroideremia

Abstract:
Background: Characterisation of preserved autofluorescence (PAF) area in choroideremia (CHM) and its validity for monitoring disease progression in clinical trials is of importance. Methods: Eighty patients with molecularly confirmed CHM were recruited. PAF area was measured manually by 2 graders and half-life was calculated based on exponential decay model. Results: Mean age at baseline and follow-up examination was 38.1 (range, 10–69) and... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/jcm10020232

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Role:
Author
ORCID:
0000-0002-5108-2179
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Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-9878-4621
Publisher:
MDPI
Journal:
Journal of Clinical Medicine More from this journal
Volume:
10
Issue:
2
Article number:
232
Publication date:
2021-01-11
Acceptance date:
2020-12-29
DOI:
EISSN:
2077-0383
Language:
English
Keywords:
Pubs id:
1154126
Local pid:
pubs:1154126
Deposit date:
2021-01-12

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