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Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.

Abstract:

The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi- and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20131189

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Journal of experimental medicine More from this journal
Volume:
211
Issue:
2
Pages:
181-188
Publication date:
2014-02-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:447751
UUID:
uuid:fc190921-e951-4648-9ffd-acd57266c17b
Local pid:
pubs:447751
Source identifiers:
447751
Deposit date:
2014-02-21

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