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Scrapie epidemic in a fully PrP-genotyped sheep flock.

Abstract:

In scrapie-affected sheep flocks, host PrP genotype plays a vital role in determining which sheep will succumb to scrapie and the incubation period. Consequently, within-flock scrapie dynamics is best understood within the context of the genotype profile of the flock. Here we describe a 17 month epidemic of scrapie in a commercially farmed flock of 230 genotyped Texel sheep. At the start of the study, 70% of the sheep were of three genotypes only: ARR/ARQ, ARH/ARQ and ARQ/ARQ. Only 15% of she...

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Publication status:
Published

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Authors


Goldmann, W More by this author
Houston, F More by this author
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Journal:
The Journal of general virology
Volume:
83
Issue:
Pt 11
Pages:
2907-2914
Publication date:
2002-11-05
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:fc09dc54-94e0-4b16-8def-98aee1202943
Source identifiers:
210200
Local pid:
pubs:210200

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