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In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate.

Abstract:

BACKGROUND: The use of in vivo (13)C nuclear magnetic resonance spectroscopy in probing metabolic pathways to study normal metabolism and characterize disease physiology has been limited by its low sensitivity. However, recent technological advances have enabled greater than 50,000-fold enhancement of liquid-state polarization of metabolically active (13)C substrates, allowing for rapid assessment of (13)C metabolism in vivo. The present study applied hyperpolarized (13)C magnetic resonance s...

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Publisher copy:
10.1007/s11307-009-0218-z

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Journal:
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging More from this journal
Volume:
11
Issue:
6
Pages:
399-407
Publication date:
2009-01-01
DOI:
EISSN:
1860-2002
ISSN:
1536-1632
Language:
English
Keywords:
Pubs id:
pubs:239223
UUID:
uuid:fbfa1634-16ce-4608-b49b-78fbdbcc6440
Local pid:
pubs:239223
Source identifiers:
239223
Deposit date:
2012-12-19

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