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Journal article

The influence of molecular reach and diffusivity on the efficacy of membrane-confined reactions

Abstract:

Signaling by surface receptors often relies on tethered reactions whereby an enzyme bound to the cytoplasmic tail of a receptor catalyzes reactions on substrates within reach. The overall length and stiffness of the receptor tail, the enzyme, and the substrate determine a biophysical parameter termed the molecular reach of the reaction. This parameter determines the probability that the receptor-tethered enzyme will contact the substrate in the volume proximal to the membrane when separated b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-9018-1997
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-5847-5226
More from this funder
Name:
Wellcome Trust
Funding agency for:
Dushek, O
Grant:
Senior Research Fellowship in Basic Biomedical Science (207537/Z/17/Z
Publisher:
Cell Press
Journal:
Biophysical Journal More from this journal
Volume:
117
Issue:
7
Pages:
1189-1201
Publication date:
2019-08-28
Acceptance date:
2019-08-22
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Keywords:
Pubs id:
pubs:927682
UUID:
uuid:fbf43cde-7852-408c-bab5-f165efaeb8d2
Local pid:
pubs:927682
Source identifiers:
927682
Deposit date:
2018-11-07

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