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Unilateral lesions of the cholinergic basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys.

Abstract:

It has been proposed that isolation of the inferior temporal cortex and medial temporal lobe from their cholinergic afferents results in a severe anterograde amnesia. To test this hypothesis directly, seven rhesus monkeys received a unilateral immunotoxic lesion of the cholinergic cells of the basal forebrain with an ipsilesional section of the fornix. In a second surgery, inferior temporal cortex was ablated in the opposite hemisphere. All animals were severely impaired at learning visual sc...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/12.7.729

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Cerebral cortex (New York, N.Y. : 1991) More from this journal
Volume:
12
Issue:
7
Pages:
729-736
Publication date:
2002-07-01
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Language:
English
Keywords:
Pubs id:
pubs:28109
UUID:
uuid:fbf40650-3037-4f70-9af2-97601a2e3247
Local pid:
pubs:28109
Source identifiers:
28109
Deposit date:
2012-12-19

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