- Abstract:
-
The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells. Cish was rapidly induced in response to IL-15, and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by enhanced proliferation, survival, IFN-γ producti...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 28.9MB)
-
- Publisher copy:
- 10.1038/ni.3470
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Immunology Journal website
- Volume:
- 17
- Issue:
- 7
- Pages:
- 816-824
- Publication date:
- 2016-05-05
- Acceptance date:
- 2016-04-27
- DOI:
- ISSN:
-
1529-2908 and 1529-2916
- Pubs id:
-
pubs:625356
- URN:
-
uri:fbf10c7e-6227-4864-9b85-904763895df1
- UUID:
-
uuid:fbf10c7e-6227-4864-9b85-904763895df1
- Local pid:
- pubs:625356
- Language:
- English
- Keywords:
- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2016
- Notes:
- © 2016 Nature America, Inc. All rights reserved.
Journal article
CIS is a potent checkpoint in NK cell-mediated tumor immunity.
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