Journal article
CIS is a potent checkpoint in NK cell-mediated tumor immunity.
- Abstract:
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The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells. Cish was rapidly induced in response to IL-15, and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by enhanced proliferation, survival, IFN-γ producti...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 28.9MB)
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- Publisher copy:
- 10.1038/ni.3470
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Authors
Funding
Canada Foundation for Innovation
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Eshelman Institute for Innovation
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Innovative Medicines Initiative (EU/EFPIA)
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Janssen
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Merck & Co.
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Immunology Journal website
- Volume:
- 17
- Issue:
- 7
- Pages:
- 816-824
- Publication date:
- 2016-05-01
- Acceptance date:
- 2016-04-27
- DOI:
- ISSN:
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1529-2908 and 1529-2916
- Pmid:
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27213690
- Source identifiers:
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625356
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:625356
- UUID:
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uuid:fbf10c7e-6227-4864-9b85-904763895df1
- Local pid:
- pubs:625356
- Deposit date:
- 2018-01-16
Terms of use
- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2016
- Notes:
- © 2016 Nature America, Inc. All rights reserved.
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