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CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Abstract:

The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells. Cish was rapidly induced in response to IL-15, and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by enhanced proliferation, survival, IFN-γ producti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ni.3470

Authors


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Bayer Pharma AG More from this funder
Boehringer Ingelheim More from this funder
Canada Foundation for Innovation More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Immunology Journal website
Volume:
17
Issue:
7
Pages:
816-824
Publication date:
2016-05-05
Acceptance date:
2016-04-27
DOI:
ISSN:
1529-2908 and 1529-2916
Pubs id:
pubs:625356
URN:
uri:fbf10c7e-6227-4864-9b85-904763895df1
UUID:
uuid:fbf10c7e-6227-4864-9b85-904763895df1
Local pid:
pubs:625356

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