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Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment

Abstract:

Background: Signal Regulatory Protein γ (SIRPγ) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. SIRPγ is expressed on T lymphocytes where it appears to be involved in the integrin-independent adhesion of lymphocytes to antigen-presenting cells. Here we describe the first full length structure of the extracellular region of human SIRPγ.

Results: We obtained crystals of SI...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1472-6807-13-13

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Name:
Medical Research Council
Funding agency for:
Hatherley, D
Stuart, D
Barclay, N
Grant:
G9826026
G9826026
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Name:
Wellcome Trust
Grant:
075491/Z/04
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Name:
Biotechnology and Biological Sciences Research Council
Publisher:
BioMed Central
Journal:
BMC structural biology More from this journal
Volume:
13
Issue:
1
Pages:
13
Publication date:
2013-01-01
DOI:
EISSN:
1472-6807
ISSN:
1472-6807
Language:
English
Keywords:
Pubs id:
pubs:410916
UUID:
uuid:fbd977cc-ed73-4274-86d1-fe142caa4edc
Local pid:
pubs:410916
Source identifiers:
410916
Deposit date:
2013-11-16

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