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Heterosexual transmission of subtype C HIV-1 selects consensus-like variants without increased replicative capacity or interferon-α resistance

Abstract:

Heterosexual transmission of HIV-1 is characterized by a genetic bottleneck that selects a single viral variant, the transmitted/founder (TF), during most transmission events. To assess viral characteristics influencing HIV-1 transmission, we sequenced 167 near full-length viral genomes and generated 40 infectious molecular clones (IMC) including TF variants and multiple non-transmitted (NT) HIV-1 subtype C variants from six linked heterosexual transmission pairs near the time of transmission...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Public Library of Science
Journal:
PLoS pathogens More from this journal
Volume:
11
Issue:
9
Pages:
e1005154
Publication date:
2015-09-17
Acceptance date:
2015-08-17
DOI:
EISSN:
1553-7374
ISSN:
1553-7366

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