- Abstract:
-
Posttranslational modification by ubiquitin controls multiple cellular functions and is counteracted by the activities of deubiquitinating enzymes. UBPy (USP8) is a growth-regulated ubiquitin isopeptidase that interacts with the HRS-STAM complex. Using Cre-loxP-mediated gene targeting in mice, we show that lack of UBPy results in embryonic lethality, whereas its conditional inactivation in adults causes fatal liver failure. The defect is accompanied by a strong reduction or absence of several...
Expand abstract - Publisher copy:
- 10.1128/MCB.01566-06
-
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- Journal:
- Molecular and Cellular Biology
- Volume:
- 27
- Issue:
- 13
- Pages:
- 5029-5039
- Publication date:
- 2007-07-05
- DOI:
- ISSN:
-
0270-7306
- URN:
-
uuid:fbd0e606-229a-4713-b6d6-4b3f73ed86df
- Source identifiers:
-
178480
- Local pid:
- pubs:178480
- Language:
- English
- Copyright date:
- 2007
Journal article
Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo
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