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Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

Abstract:

Posttranslational modification by ubiquitin controls multiple cellular functions and is counteracted by the activities of deubiquitinating enzymes. UBPy (USP8) is a growth-regulated ubiquitin isopeptidase that interacts with the HRS-STAM complex. Using Cre-loxP-mediated gene targeting in mice, we show that lack of UBPy results in embryonic lethality, whereas its conditional inactivation in adults causes fatal liver failure. The defect is accompanied by a strong reduction or absence of several...

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Publisher copy:
10.1128/MCB.01566-06

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Journal:
Molecular and Cellular Biology
Volume:
27
Issue:
13
Pages:
5029-5039
Publication date:
2007-07-05
DOI:
ISSN:
0270-7306
URN:
uuid:fbd0e606-229a-4713-b6d6-4b3f73ed86df
Source identifiers:
178480
Local pid:
pubs:178480
Language:
English

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