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Journal article

Synergistic activity of letrozole and sorafenib on breast cancer cells.

Abstract:

Estrogens induce breast tumor cell proliferation by directly regulating gene expression via the estrogen receptor (ER) transcriptional activity and by affecting growth factor signaling pathways such as mitogen-activated protein kinase (MAPK) and AKT/mammalian target of rapamycin Complex1 (mTORC1) cascades. In this study we demonstrated the preclinical therapeutic efficacy of combining the aromatase inhibitor letrozole with the multi-kinase inhibitor sorafenib in aromatase-expressing breast ca...

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Publication status:
Published

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Publisher copy:
10.1007/s10549-009-0714-5

Authors


Bonelli, MA More by this author
Fumarola, C More by this author
Alfieri, RR More by this author
La Monica, S More by this author
Cavazzoni, A More by this author
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Journal:
Breast cancer research and treatment
Volume:
124
Issue:
1
Pages:
79-88
Publication date:
2010-11-05
DOI:
EISSN:
1573-7217
ISSN:
0167-6806
URN:
uuid:fbcc3c3e-3df4-424c-a779-af89c4db4264
Source identifiers:
125288
Local pid:
pubs:125288

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