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Assessing white matter ischemic damage in dementia patients by measurement of myelin proteins.

Abstract:

White matter ischemia is difficult to quantify histologically. Myelin-associated glycoprotein (MAG) is highly susceptible to ischemia, being expressed only adaxonally, far from the oligodendrocyte cell body. Myelin-basic protein (MBP) and proteolipid protein (PLP) are expressed throughout the myelin sheath. We compared MAG, MBP, and PLP levels in parietal white matter homogenates from 17 vascular dementia (VaD), 49 Alzheimer's disease (AD), and 33 control brains, after assessing the post-mort...

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Publisher copy:
10.1038/jcbfm.2013.46

Authors


Wellington, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
33
Issue:
7
Pages:
1050-1057
Publication date:
2013-07-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:fbb8480b-a54f-4441-90d2-331c549e2a80
Source identifiers:
390948
Local pid:
pubs:390948

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