- Abstract:
-
The key requirements for high-throughput single-nucleotide polymorphism (SNP) typing of DNA samples in large-scale disease case-control studies are automatability, simplicity, and robustness, coupled with minimal cost. In this paper we describe a fluorescence technique for the detection of SNPs that have been amplified by using the amplification refractory mutation system (ARMS)-PCR procedure. Its performance was evaluated using 32 sequence-specific primer mixes to assign the HLA-DRB alleles ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.041619998
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 98
- Issue:
- 5
- Pages:
- 2694-2697
- Publication date:
- 2001-02-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:fbae174d-d25d-42af-ad87-eef4d6b39d5f
- Source identifiers:
-
178107
- Local pid:
- pubs:178107
- Copyright date:
- 2001
Journal article
Alkaline-mediated differential interaction (AMDI): a simple automatable single-nucleotide polymorphism assay.
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