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Alkaline-mediated differential interaction (AMDI): a simple automatable single-nucleotide polymorphism assay.

Abstract:

The key requirements for high-throughput single-nucleotide polymorphism (SNP) typing of DNA samples in large-scale disease case-control studies are automatability, simplicity, and robustness, coupled with minimal cost. In this paper we describe a fluorescence technique for the detection of SNPs that have been amplified by using the amplification refractory mutation system (ARMS)-PCR procedure. Its performance was evaluated using 32 sequence-specific primer mixes to assign the HLA-DRB alleles ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.041619998

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
98
Issue:
5
Pages:
2694-2697
Publication date:
2001-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:fbae174d-d25d-42af-ad87-eef4d6b39d5f
Source identifiers:
178107
Local pid:
pubs:178107

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