Journal article icon

Journal article

Sequential desymmetrization-fluorination: enantioselective synthesis of fluorinated cyclitols.

Abstract:

An asymmetric synthesis of enantioenriched, highly functionalized fluorinated carbocycles has been developed based on an enantioselective Sharpless dihydroxylation of cyclohexadienylsilanes, combined with a diastereoselective electrophilic fluorodesilylation. Several parameters define the level of diastereocontrol for the fluorination step. These include the relative stereochemistry of the starting endocyclic allylsilanes and the structural features of the reactants. As expected for an S(E)2'...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/chem.200600861

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemistry (Weinheim an der Bergstrasse, Germany) More from this journal
Volume:
12
Issue:
36
Pages:
9176-9185
Publication date:
2006-12-01
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Language:
English
Keywords:
Pubs id:
pubs:33649
UUID:
uuid:fbab708c-32bc-4c34-906b-379d6316f317
Local pid:
pubs:33649
Source identifiers:
33649
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP