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[H-1, N-15] NMR studies of the platination of phosphorothioate nucleotides - Monofunctional sulfur adducts versus macrochelation

Abstract:
cis-[PtI2(15NH3)2] reacts rapidly with guanosine-5′-O-(2-thiodiphosphate) (GDP-β-S) to form a macrochelate in which Pt bridges the phosphorothioate S and guanine N7 atoms. Phosphorothioate(α-S)-containing self-complementary decamer oligonucleotides give rise to relatively long lived S-bound monofunctional adducts, the fate of which is sequence dependent.
Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY More from this journal
Issue:
11
Pages:
2743-2746
Publication date:
2001-11-01
ISSN:
1434-1948
Language:
English
Keywords:
Pubs id:
pubs:400232
UUID:
uuid:fba94477-0230-47b9-bbe6-3fd4329eb095
Local pid:
pubs:400232
Source identifiers:
400232
Deposit date:
2013-11-16

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