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Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease

Abstract:

Although only a small fraction will ever develop the active form of tuberculosis (ATB) disease, chemoprophylaxis treatment in latent TB infected (LTBI) individuals is an effective strategy to control pathogen transmission. Characterizing immune responses in LTBI upon chemoprophylactic treatment is important to facilitate treatment monitoring, and thus improve TB control strategies. Here, we studied changes in the blood transcriptome in a cohort of 42 LTBI and 8 ATB participants who received a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tube.2021.102127

Authors


Publisher:
Elsevier
Journal:
Tuberculosis More from this journal
Volume:
131
Article number:
102127
Publication date:
2021-09-14
Acceptance date:
2021-09-09
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
Pmid:
34555657
Language:
English
Keywords:
Pubs id:
1195954
Local pid:
pubs:1195954
Deposit date:
2021-10-04

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