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Journal article

A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.

Abstract:

RUNX1 is known to be an essential transcription factor for generating hematopoietic stem cells (HSC), but much less is known about its role in the downstream process of hematopoietic differentiation. RUNX1 has been shown to be part of a large transcription factor complex, together with LDB1, GATA1, TAL1, and ETO2 (N. Meier et al., Development 133:4913-4923, 2006) in erythroid cells. We used a tagging strategy to show that RUNX1 interacts with two novel protein partners, LSD1 and MYEF2, in ery...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.05938-11

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Journal:
Molecular and cellular biology
Volume:
32
Issue:
19
Pages:
3814-3822
Publication date:
2012-10-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:fb9d71fa-3195-44b0-aaee-1883a1a4bc45
Source identifiers:
342327
Local pid:
pubs:342327

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