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Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation

Abstract:

Rationale: Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthases (NOS). Oral BH4 supplementation preserves cardiac function in animal models of cardiac disease; however, the mechanisms underlying these findings are not completely understood. Objective: To study the effect of myocardial transgenic overexpression of the rate-limiting enzyme in BH4 biosynthesis, GTP cyclohydrolase 1 (GCH1), on NOS activity, myocardial function, and Ca handling. Methods and Results: GCH1ove...

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Journal:
Circulation Research More from this journal
Volume:
111
Issue:
6
Pages:
718-727
Publication date:
2012-08-31
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:352775
UUID:
uuid:fb9d02dd-f14a-484d-96c7-8993a3aea320
Local pid:
pubs:352775
Source identifiers:
352775
Deposit date:
2013-11-17

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