Journal article
Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability
- Abstract:
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BACKGROUND:Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. METHODS:We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.1MB)
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- Publisher copy:
- 10.1016/j.ebiom.2018.08.004
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 35
- Pages:
- 279-287
- Publication date:
- 2018-08-14
- Acceptance date:
- 2018-08-03
- DOI:
- EISSN:
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2352-3964
- Pmid:
-
30120083
- Source identifiers:
-
976578
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:976578
- UUID:
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uuid:fb970020-ab89-4cbb-b5c2-ce7d9f70726c
- Local pid:
- pubs:976578
- Deposit date:
- 2019-03-12
Terms of use
- Copyright holder:
- Ferguson et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier B.V.
- Licence:
- CC Attribution (CC BY)
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