- Abstract:
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BACKGROUND:Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. METHODS:We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investi...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.1MB)
-
- Publisher copy:
- 10.1016/j.ebiom.2018.08.004
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- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 35
- Pages:
- 279-287
- Publication date:
- 2018-08-14
- Acceptance date:
- 2018-08-03
- DOI:
- EISSN:
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2352-3964
- Pubs id:
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pubs:976578
- URN:
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uri:fb970020-ab89-4cbb-b5c2-ce7d9f70726c
- UUID:
-
uuid:fb970020-ab89-4cbb-b5c2-ce7d9f70726c
- Local pid:
- pubs:976578
- Language:
- English
- Keywords:
- Copyright holder:
- Ferguson et al.
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier B.V.
Journal article
Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability
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