Journal article icon

Journal article

Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability

Abstract:

BACKGROUND:Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. METHODS:We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.ebiom.2018.08.004

Authors


Expand authors...
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
35
Pages:
279-287
Publication date:
2018-08-14
Acceptance date:
2018-08-03
DOI:
EISSN:
2352-3964
Pmid:
30120083
Source identifiers:
976578
Language:
English
Keywords:
Pubs id:
pubs:976578
UUID:
uuid:fb970020-ab89-4cbb-b5c2-ce7d9f70726c
Local pid:
pubs:976578
Deposit date:
2019-03-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP