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Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability

Abstract:

BACKGROUND:Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. METHODS:We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.ebiom.2018.08.004

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Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
35
Pages:
279-287
Publication date:
2018-08-14
Acceptance date:
2018-08-03
DOI:
EISSN:
2352-3964
Pubs id:
pubs:976578
URN:
uri:fb970020-ab89-4cbb-b5c2-ce7d9f70726c
UUID:
uuid:fb970020-ab89-4cbb-b5c2-ce7d9f70726c
Local pid:
pubs:976578
Language:
English
Keywords:

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