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Journal article

Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

Abstract:

Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acety...

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Publication status:
Published

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Publisher copy:
10.1038/ng.572

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Journal:
Nature genetics More from this journal
Volume:
42
Issue:
5
Pages:
436-440
Publication date:
2010-05-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Keywords:
Pubs id:
pubs:94842
UUID:
uuid:fb8fb72b-abef-4f82-b70f-07f6fa9d37fc
Local pid:
pubs:94842
Source identifiers:
94842
Deposit date:
2012-12-19

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