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Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36.

Abstract:

Set2 (KMT3)-dependent methylation (me) of histone H3 at lysine 36 (H3K36) promotes deacetylation of transcribed chromatin and represses cryptic promoters within genes. Although Set2 is the only methyltransferase (KMTase) for H3K36 in yeast, it is not known if Set2 is regulated or whether the different methylation states at H3K36 are functionally distinct. Here we show that the N-terminal 261 residues of Set2 (Set2(1-261)), containing the SET KMTase domain, are sufficient for H3K36me2, histone...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.00001-08

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Journal:
Molecular and cellular biology
Volume:
28
Issue:
16
Pages:
4915-4926
Publication date:
2008-08-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:fb8faf5d-bc9c-4fe1-b364-3b21733c350f
Source identifiers:
101208
Local pid:
pubs:101208

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