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DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers.

Abstract:

PURPOSE: About 15% of colorectal cancers harbor microsatellite instability (MSI). MSI-associated gene expression changes have been identified in colorectal cancers, but little overlap exists between signatures hindering an assessment of overall consistency. Little is known about the causes and downstream effects of differential gene expression. EXPERIMENTAL DESIGN: DNA microarray data on 89 MSI and 140 microsatellite-stable (MSS) colorectal cancers from this study and 58 MSI and 77 MSS cases...

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Authors


Jorissen, RN More by this author
Chapman, M More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
14
Issue:
24
Pages:
8061-8069
Publication date:
2008-12-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:fb8e74ae-467c-4d23-b463-3785f1b1f178
Source identifiers:
72278
Local pid:
pubs:72278

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