Thesis icon

Thesis

IRF5 directs colonic inflammation and control of mononuclear phagocyte adaptation to the tissue environment

Abstract:

Macrophages are leukocytes of the innate immune system that display great phenotypic plasticity to mediate diverse functions. The ontogeny of tissue resident macrophages has been debated in recent decades. It is now recognised that tissue macrophages can be replenished from embryonically-derived precursors, and/or monocyte intermediates in a tissue specific manner.

Interferon Regulatory Factor 5 (IRF5) is a transcription factor that promotes a pro-inflammatory phenotype in macropha...

Expand abstract

Actions


Authors


More by this author
Department:
Kennedy Institute of Rheumatology

Contributors

Department:
Kennedy Institute of Rheumatology
Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP