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Journal article

Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis.

Abstract:

OBJECTIVE: Neurodegeneration is now accepted as a pathologic hallmark of multiple sclerosis (MS). We sought to discover whether CSF levels of neurofilament heavy chain protein (NfH(SMI35)) correlate with disability, disease activity, or specific stages of MS. METHODS: An electrochemiluminescence immunoassay was used to retrospectively measure NfH(SMI35) in CSF of patients with clinically isolated syndrome (CIS) (n = 63), relapsing-remitting multiple sclerosis (RRMS) (n = 39), secondary progr...

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Publication status:
Published

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Journal:
Neurology
Volume:
76
Issue:
14
Pages:
1206-1213
Publication date:
2011-04-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:fb7ce796-deae-44ca-a370-2d33ab556c7d
Source identifiers:
185187
Local pid:
pubs:185187

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