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Activation of ADP-ribosylation factor regulates biogenesis of the ATP7A-containing trans-Golgi network compartment and its Cu-induced trafficking.

Abstract:

ATP7A (MNK) regulates copper homeostasis by translocating from a compartment localized within the trans-Golgi network to the plasma membrane (PM) in response to increased copper load. The mechanisms that regulate the biogenesis of the MNK compartment and the trafficking of MNK are unclear. Here we show that the architecture of the MNK compartment is linked to the structure of the Golgi ribbon. Depletion of p115 tethering factor, which causes fragmentation of the Golgi ribbon, also disrupts th...

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Publication status:
Published

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Publisher copy:
10.1152/ajpcell.00253.2007

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Journal:
American journal of physiology. Cell physiology
Volume:
293
Issue:
6
Pages:
C1753-C1767
Publication date:
2007-12-05
DOI:
EISSN:
1522-1563
ISSN:
0363-6143
URN:
uuid:fb7b92b3-aeee-4e43-87d3-fe507412c453
Source identifiers:
33995
Local pid:
pubs:33995

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