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Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.

Abstract:

ATP-dependent priming of the secretory granules precedes Ca(2+)-regulated neuroendocrine secretion, but the exact nature of this reaction is not fully established in all secretory cell types. We have further investigated this reaction in the insulin-secreting pancreatic B-cell and demonstrate that granular acidification driven by a V-type H(+)-ATPase in the granular membrane is a decisive step in priming. This requires simultaneous Cl(-) uptake through granular ClC-3 Cl(-) channels. According...

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Publication status:
Published

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Journal:
Journal of cell science
Volume:
114
Issue:
Pt 11
Pages:
2145-2154
Publication date:
2001-06-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:fb795447-d446-42b9-8402-0887fdd9200f
Source identifiers:
27010
Local pid:
pubs:27010

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