Journal article icon

Journal article

p53-specific CD8+ T-cell responses in individuals with cutaneous squamous cell carcinoma.

Abstract:

BACKGROUND: Systemic immunosuppression is a significant risk factor for cutaneous squamous cell carcinoma (SCC). p53 is mutated and overexpressed in up to 90% of cutaneous SCC lesions. Despite considerable evidence that the immune response is important in the control of cutaneous SCC, there are no studies documenting potential tumour-associated antigens. OBJECTIVES: We tested the hypothesis that individuals with cutaneous SCC have functional circulating CD8+ T cells specific for p53. METHODS:...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Turner, RJ More by this author
Hollowood, K More by this author
Expand authors...
Journal:
The British journal of dermatology
Volume:
153
Issue:
5
Pages:
987-991
Publication date:
2005-11-05
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
URN:
uuid:fb7620fa-9ccc-48ee-a133-3980333f21ad
Source identifiers:
23824
Local pid:
pubs:23824

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP