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Journal article

p53 methylation--the Arg-ument is clear.

Abstract:

p53 Activity is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumors have defective or inactive p53. In normal cells, p53 is held at low levels in a latent form and, following DNA damage, is stabilized which usually results in apoptosis or cell cycle arrest. Most functions of p53 can be ascribed to its role as a sequence specific transcription factor, and an extensive repertoire of downstream responsive genes have been identif...

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Publication status:
Published

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Publisher copy:
10.4161/cc.8.6.7850
Journal:
Cell cycle (Georgetown, Tex.) More from this journal
Volume:
8
Issue:
6
Pages:
801-802
Publication date:
2009-03-01
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
Language:
English
Keywords:
Pubs id:
pubs:256545
UUID:
uuid:fb72e47e-393d-489b-a8ae-5275c289412f
Local pid:
pubs:256545
Source identifiers:
256545
Deposit date:
2012-12-19

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