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A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response

Abstract:

The glucocorticoid receptor (GR) is essential for the stress response in mammals. We investigated potential non-transcriptional roles of GR in cellular stress response using fission yeast as a model.We surprisingly discovered marked heat stress resistance in yeast ectopically expressing human GR, which required expression of both the N-terminal transactivation domain, and the C-terminal ligand binding domain, but not the DNA-binding domain of the GR. This effect was not affected by GR ligand ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-0653-405X
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Name:
Medical Research Council
Grant:
MR/M008959/1
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
7
Issue:
1
Article number:
12101
Publication date:
2017-09-21
Acceptance date:
2017-07-17
DOI:
ISSN:
2045-2322
Pmid:
28935859
Language:
English
Pubs id:
pubs:918597
UUID:
uuid:fb6ea87f-5672-425a-90d5-0fb246617525
Local pid:
pubs:918597
Source identifiers:
918597
Deposit date:
2018-10-18

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