Sustained remission of severe resistant autoimmune neutropenia with Campath-1H.

Journal article

We report the course of a patient with severe autoimmune neutropenia in whom only transient responses occurred with corticosteroids, antilymphocyte globulin and granulocyte-colony stimulating factor, and who was resistant to treatment with azathioprine, cyclosporin and intravenous immunoglobulin. A 10 d course of intravenous Campath-1H monoclonal resulted in a sustained haematological response. The long-lasting effect of Campath-1H may be due to its remarkable ability to induce a profound and prolonged peripheral blood T lymphopenia.

Authors: Killick, S; Marsh, J; Hale, G; Waldmann, H; Kelly, S

• Publication status: Published
• Journal: British journal of haematology
• Volume: 97
• Issue: 2
• Pages: 306-308
• Publication date: 1997-05-01
• DOI: 10.1046/j.1365-2141.1997.612718.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Infusions, Intravenous; Female; Leukocyte Count; Autoimmune Diseases; Antibodies, Neoplasm; Antibodies, Monoclonal; Middle Aged; Antibodies, Monoclonal, Humanized; Humans; Neutropenia