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Sustained remission of severe resistant autoimmune neutropenia with Campath-1H.

Abstract:
We report the course of a patient with severe autoimmune neutropenia in whom only transient responses occurred with corticosteroids, antilymphocyte globulin and granulocyte-colony stimulating factor, and who was resistant to treatment with azathioprine, cyclosporin and intravenous immunoglobulin. A 10 d course of intravenous Campath-1H monoclonal resulted in a sustained haematological response. The long-lasting effect of Campath-1H may be due to its remarkable ability to induce a profound and prolonged peripheral blood T lymphopenia.
Publication status:
Published

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Authors


Killick, SB More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
British journal of haematology
Volume:
97
Issue:
2
Pages:
306-308
Publication date:
1997-05-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:fb6e9457-1cea-433a-a2ce-e503d8ac29ec
Source identifiers:
2342
Local pid:
pubs:2342

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