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Journal article

Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.

Abstract:
We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved in an ATP-dependent resistance mechanism analogous to pyrophosphorolysis, whereas the mechanism for RT with the Q151M or V75T mutation appears to be independent of added ATP for reducing binding to d4T-triphosphate.
Publication status:
Published

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Journal:
Antimicrobial agents and chemotherapy More from this journal
Volume:
45
Issue:
7
Pages:
2144-2146
Publication date:
2001-07-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Language:
English
Keywords:
Pubs id:
pubs:72604
UUID:
uuid:fb6cd7fd-57fe-4f4f-99ac-104c88a03c3d
Local pid:
pubs:72604
Source identifiers:
72604
Deposit date:
2012-12-19

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