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Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.

Abstract:

INTRODUCTION: Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg. METHODS: Immunoperoxidase staining for FOXP3 and CXCL12 was performed on tissue microarrays from 491 breast cancers. The hypoxia-associated marker carbonic anhydrase IX (CA9) and double FOXP3/CXCR4 staining were p...

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Publication status:
Published

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Publisher copy:
10.1186/bcr2869

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Journal:
Breast cancer research : BCR More from this journal
Volume:
13
Issue:
2
Pages:
R47
Publication date:
2011-01-01
DOI:
EISSN:
1465-542X
ISSN:
1465-5411

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