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Thesis

The molecular basis for ER tubule formation

Abstract:

Integral membrane proteins of the DP1 and reticulon families are responsible for maintaining the high membrane curvature required for both smooth ER tubules and the edges of ER sheets. Mutations in these proteins lead to motor neurone diseases such as hereditary spastic paraplegia. Reticulon/DP1 proteins contain Reticulon Homology Domains (RHD) that have unusually long (≈30 aa) hydrophobic segments and are proposed to adopt intramembrane helical hairpins that stabilise membrane curvature. ...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
More from this funder
Name:
Wellcome Trust
Funding agency for:
Brady, J
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:fb5ce78d-0bc8-46dd-9552-04f1f1ec1d0f
Local pid:
ora:11731
Deposit date:
2015-06-24

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