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A humanized monovalent CD3 antibody which can activate homologous complement.

Abstract:

The rat monoclonal antibody (mAb) YTH12.5, specific for the CD3 antigen complex on human T cells has been modified in order to improve its efficacy in human therapy. With the aim of rendering it less immunogenic, it has been humanized using the method of framework grafting. During this process sequence analysis of the YTH12.5 VL gene indicated that it was of the lambda subclass, however, it was markedly dissimilar from previously published rat and mouse V lambda gene sequences and may represe...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830211111

Authors


Routledge, EG More by this author
Gorman, SD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
European journal of immunology
Volume:
21
Issue:
11
Pages:
2717-2725
Publication date:
1991-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:fb503418-f7d7-4519-8869-8fdc9c2bb4b5
Source identifiers:
28038
Local pid:
pubs:28038

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