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Quantitative dynamics of phosphoproteome: the devil is in the details.

Abstract:

Recent advances in peptide-based (bottom-up) quantitative proteomics and bioinformatics have opened unprecedented opportunities for extensive investigation of cellular proteomes and their dynamics. Here we discuss two approaches currently used to investigate the global dynamics of phosphorylation based on the isolation of phosphorylated proteins or peptides. We evaluate the accuracy of these methodologies to grasp the global dynamics of phosphorylation, and we raise awareness on ambiguities i...

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Publication status:
Published

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Publisher copy:
10.1021/ac301833k

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Analytical chemistry
Volume:
84
Issue:
20
Pages:
8431-8436
Publication date:
2012-10-05
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
URN:
uuid:fb4d509e-d2f2-4371-bc85-0a3d2c0dc2fe
Source identifiers:
353919
Local pid:
pubs:353919

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