Journal article
Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia
- Abstract:
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Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and is linked to atopic disorders in offspring. Here we show reduction of fetal thymic size, altered thymic architecture and reduced fetal thymic regulatory T (Treg) cell output in preeclamptic pregnancies, which persists up to 4 years of age in human offspring. In germ-free mice, fetal thymic CD4+ T cell and Treg cell development are compro...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 6.9MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-019-10703-1
Authors
Contributors
+ Dwyer, T
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women's and Reproductive Health
Department:
Oxford, MSD, Womens & Reproductive Health
Role:
Contributor
Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 10
- Issue:
- 1
- Article number:
- 3031
- Publication date:
- 2019-07-10
- Acceptance date:
- 2019-05-23
- DOI:
- EISSN:
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2041-1723
- Pmid:
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31292453
Item Description
- Language:
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English
- Keywords:
-
- Pubs id:
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pubs:1035719
- UUID:
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uuid:fb423aaa-0136-4b45-8626-622ad5ed131c
- Local pid:
-
pubs:1035719
- Source identifiers:
-
1035719
- Deposit date:
-
2019-12-03
Terms of use
- Copyright holder:
- Hu et al
- Copyright date:
- 2019
- Notes:
- Copyright © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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