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Journal article

Matrix metalloproteinase-1 and -9 promoter polymorphisms are not associated with an increased risk of uterine leiomyomas in a Japanese population.

Abstract:

OBJECTIVE: Matrix metalloproteinases (MMPs) play an important role in modeling and remodeling the extracellular matrix in leiomyomas. Hence, we investigated whether associations exist between leiomyomas and promoter polymorphisms in the MMP-1 and MMP-9 genes in a Japanese population. METHODS: We compared the distribution of polymorphisms in the promoter regions of MMP-1 (-1607 1G/2G) and MMP-9 (-1562 C/T) in 267 leiomyoma patients and 184 control patients using polymerase chain reaction-frag...

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Publication status:
Published

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Publisher copy:
10.1016/j.jsgi.2006.02.004

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Journal:
Journal of the Society for Gynecologic Investigation
Volume:
13
Issue:
3
Pages:
232-236
Publication date:
2006-04-05
DOI:
EISSN:
1556-7117
ISSN:
1071-5576
URN:
uuid:fb3949bb-6eb9-4965-b440-875e68d8e262
Source identifiers:
321934
Local pid:
pubs:321934

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