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Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.

Abstract:

Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) is activated by DNA single-strand breaks (SSB) or at stalled replication forks to facilitate DNA repair. Inhibitors of PARP efficiently kill breast, ovarian, or prostate tumors in patients carrying hereditary mutations in the homologous recombination (HR) genes BRCA1 or BRCA2 through synthetic lethality. Here, we surprisingly show that PARP1 is hyperactivated in replicating BRCA2-defective cells. PARP1 hyperactivation is explained by the defect in H...

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Publication status:
Published

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Journal:
Cancer research More from this journal
Volume:
70
Issue:
13
Pages:
5389-5398
Publication date:
2010-07-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Language:
English
Keywords:
Pubs id:
pubs:130874
UUID:
uuid:fb379cee-745f-45b2-8468-0feb4ca2dfec
Local pid:
pubs:130874
Source identifiers:
130874
Deposit date:
2012-12-19

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