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The core of bluetongue virus binds double-stranded RNA.

Abstract:
Double-stranded RNA (dsRNA) viruses conceal their genome from the host to avoid triggering unfavorable cellular responses. The crystal structure of the core of one such virus, bluetongue virus, reveals an outer surface festooned with dsRNA. This may represent a deliberate strategy to sequester dsRNA released from damaged particles to prevent host cell shutoff.
Publication status:
Published

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Authors


Diprose, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Sutton, GC More by this author
Burroughs, JN More by this author
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Journal:
Journal of virology
Volume:
76
Issue:
18
Pages:
9533-9536
Publication date:
2002-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:fb343644-0136-4984-ba45-35a72fd6e8fe
Source identifiers:
22971
Local pid:
pubs:22971

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