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Analysing steroid modulation of BK(Ca) channels reconstituted into planar lipid bilayers.

Abstract:

A number of recent studies have described the activation of BK(Ca) channels by steroid hormones such as estrogen. The proposed mechanisms are diverse and include both the direct interaction with the ion channel subunits and the stimulation via receptor activation and cell signalling pathways. To investigate the activation of BK(Ca) channels by estrogen we devised a cell-free system by incorporating recombinant channels of known subunit composition into artificial bilayers and recorded single ...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Methods in molecular biology (Clifton, N.J.) More from this journal
Volume:
491
Pages:
177-186
Publication date:
2008-01-01
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
Language:
English
Keywords:
Pubs id:
pubs:237802
UUID:
uuid:fb2ae5de-cfa2-46f2-b091-e9f0f85a9185
Local pid:
pubs:237802
Source identifiers:
237802
Deposit date:
2012-12-19

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