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The frequency and amplitude of growth hormone secretory episodes as determined by deconvolution analysis are increased in adolescents with insulin dependent diabetes mellitus and are unaffected by short-term euglycaemia.

Abstract:

OBJECTIVE: High overnight plasma growth hormone (GH) levels in insulin-dependent diabetes mellitus (IDDM) are reflected in both an increase in the GH pulse amplitude and elevated baseline GH concentrations. To determine whether these are a result of an increase in GH secretory episodes, we undertook deconvolution analysis of overnight GH profiles using previously determined half-life data. DESIGN: Deconvolution of overnight GH profiles (2000-0800 h) was undertaken from normal and diabetic ado...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Clinical endocrinology More from this journal
Volume:
38
Issue:
1
Pages:
93-100
Publication date:
1993-01-01
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
Language:
English
Keywords:
Pubs id:
pubs:72792
UUID:
uuid:fb1e1cf0-fec3-4e0c-9c8c-0aac283f5b88
Local pid:
pubs:72792
Source identifiers:
72792
Deposit date:
2012-12-19

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