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Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains.

Abstract:

Staphylococcus aureus can adhere to and invade endothelial cells by binding to the human protein fibronectin (Fn). FnBPA and FnBPB, cell wall-attached proteins from S. aureus, have multiple, intrinsically disordered, high-affinity binding repeats (FnBRs) for Fn. Here, 30 years after the first report of S. aureus/Fn interactions, we present four crystal structures that together comprise the structures of two complete FnBRs, each in complex with four of the N-terminal modules of Fn. Each approx...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0803556105

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
34
Pages:
12254-12258
Publication date:
2008-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:fb142d2e-50e1-4858-bfda-5c71a51f6464
Source identifiers:
100741
Local pid:
pubs:100741

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