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Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria.

Abstract:

An open paired randomised comparison of intramuscular chloroquine (3.5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria. 8 children died, 6 from the quinine-treated and 2 from the chloroquine-treated group. Chloroquine reduced parasitaemia significantly more rapidly than did quinine, but other measures of the therapeutic response were similar in the two groups. Quinine injectio...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Lancet
Volume:
2
Issue:
8675
Pages:
1313-1316
Publication date:
1989-12-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:fb0fb399-dd50-485e-b173-808425461fce
Source identifiers:
43137
Local pid:
pubs:43137

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