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Membrane transporters as machines: degenerate singularities as a requirement for function.

Abstract:

It is suggested that Membrane Transporter functionality is based on low energy paths between proteins of different conformations. A simple extension of the Born-Oppenheimer approximation is used to reduce the protein structure problem to one of the kinematics of engineering mechanisms. Such low energy paths between conformations with the same handedness imply the existence of degenerate singularities in the engineering mechanism. The requirement for degeneracy leads to a number of conjectures...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2004.08.009

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Journal:
Journal of theoretical biology
Volume:
232
Issue:
2
Pages:
217-221
Publication date:
2005-01-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:fb0d7f93-5f25-4f7b-90c7-ed04b39c2250
Source identifiers:
62464
Local pid:
pubs:62464

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