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Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection.

Abstract:

Hepatitis C virus (HCV) becomes persistent in the majority of infected individuals. In doing so, the virus evades host adaptive immune responses, although the mechanisms responsible in this evasion are not clear. Several groups have demonstrated weak or absent HCV-specific CD4+ T cell responses during chronic HCV infection using proliferation assays and, more recently, class II tetramers. However, the functional status of HCV-specific CD4+ T cells in resolved and persistent infection is poorl...

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Publication status:
Published

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Publisher copy:
10.1002/hep.20669

Authors


Harcourt, G More by this author
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Journal:
Hepatology (Baltimore, Md.)
Volume:
41
Issue:
5
Pages:
1019-1028
Publication date:
2005-05-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:fb0c58bf-0c4d-4353-8840-6fb40217646a
Source identifiers:
22315
Local pid:
pubs:22315

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